BIOMARKERS FOR AMYOTROPHIC LATERAL SCLEROSIS (ALS) AND MOTOR NEURON DISEASES

摘要

Provided herein is a method comprising detecting and quantifying the amount of at least two proteins in a serum sample obtained from a subject suffering from a motor neuron disease, such as amyotrophic lateral sclerosis (ALS). The method may be used to treat the subject by measuring a change in concentration of the at least two or more proteins in the serum sample over a duration of time and administering a treatment to the subject based upon the change in concentration. The two or more proteins may be APOC3, APOF, C8B, C8G, IGHG3, ITIH3, QSOX1, SERPINA10, SERPINA5, VWF, APOA2, APOA4, APOD, APOL1, C4B, CLEC3B, CLU, APCS, BCHE, C1R, CFH, GP1BA, PROS1, SERPINA4, SEPP1, A2M, AGT, C1RL, CD14, FCN2, SERPINA1, SERPINF2, APOA1, and/or IGFBP3.