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Method for selective splicing regulation and treatment of gene expression
Method for selective splicing regulation and treatment of gene expression
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机译:基因表达的选择性剪接调控方法
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摘要
Provided herein is a chimeric transactivating minigene, and selective splicing of the minigene determines whether the transactivator is expressed. Expression of the transactivator results in transcription of the target gene under the control of the designer promoter sequence. Alternatively, provided herein is a chimeric target gene minigene, and selective splicing of the minigene directly determines whether the target gene is expressed. The target gene can be encoded for an inhibitory RNA, CRISPR-Cas9 protein or therapeutic protein.
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