methods for specifically and selectively enhancing gene expression of bone morphogenetic protein (s) in tissue, treatment device and method for determining a selective signal generating an electric field

摘要

METHOD FOR SPECIFICALLY AND SELECTIVELY IMPROVING EXPRESSION OF BONE MORPHOGENETIC PROTEIN (S) GENES IN TISSUE, DEVICE AND METHODS FOR DETERMINING A SELECTIVE SIGN THAT GENERATES A ELECTRIC FIELD bone morphogenetic protein gene in bone cells by applying fields generated by specific and selective electrical and electromagnetic signals in the treatment of diseased or injured bone. By gene expression is meant increasing or decreasing regulation of the process by which specific parts (genes) of the human genome (DNA) are transcribed into mRNA and then transformed into protein. Methods and devices are provided for the targeted treatment of injured or diseased bone tissue; which includes generating specific and selective electrical and electromagnetic signals that generate fields optimized for enhancing bone morphogenetic protein gene expression and exposing bone to specific and selective signal generated fields in such a way as to regulate bone morphogenetic protein gene expression in this bone tissue. The resulting methods and devices are useful for treating fractures, potential fractures, delayed joints, non-welding fractures, bone imperfections, spinal fusions, targeted osteonecrosis or avascular necrosis as an accessory to other therapies in the treatment of one or all. previously exposed, and in the treatment of osteoporosis.