METHODS OF MONITORING, TREATING, AND PREVENTING RENAL INFLAMMATION ASSOCIATED WITH KIDNEY TRANSPLANTATION

摘要

The invention provides methods of monitoring for renal inflammation in a kidney transplantation donor or recipient by analyzing levels one or more UDP-hexoses (such as UDP-glucose, UDP-galactose, UDP-glucuronic acid, N-acetyl-UDP-glucosamine and/or N-acetyl-UDP-galactosamine) in sample from the donor or recipient. The invention also provides methods of treating or preventing renal inflammation in a kidney transplantation donor or recipient by providing a P2Y 14 receptor antagonist to the donor, the extracted kidney, or the recipient.