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HER2-TARGETED PEPTIDOMIMETICS GRAFTED ONTO MULTICYCLIC PEPTIDE SCAFFOLDS AND METHODS AND USES
HER2-TARGETED PEPTIDOMIMETICS GRAFTED ONTO MULTICYCLIC PEPTIDE SCAFFOLDS AND METHODS AND USES
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机译:Her2靶向肽模拟物接枝到多环肽支架和方法上并用途
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摘要
A method of treating cancer in a mammalian patient comprising administering a pharmaceutical composition to the patient including a pharmacologically effective amount of a first therapeutic, wherein the first therapeutic comprises one or more HER2-targeted peptide functional groups grafted onto a cyclic scaffold, or a pharmaceutically acceptable salt, solvate, ester, amide, clathrate, stereoisomer, enantiomer, prodrug or analogs thereof. In a further embodiment, the one or more HER2-targeted peptide functional groups grafted onto a cyclic scaffold contains at least one 3-amino 3(1-napthyl) propionic acid bound to the scaffold.
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