Provided in the present invention is the use of the miR-338 cluster as a marker of postmenopausal osteoporosis. In the present invention, it was found that the miR-338 cluster such as miR-338-3p and/or miR-3065-5p are highly expressed in patients with postmenopausal osteoporosis, and it can be used as a marker of postmenopausal osteoporosis, used for preparing an auxiliary diagnostic kit for postmenopausal osteoporosis, which can specifically detect the expression level of the miR-338 cluster in tissues, and is used for non-invasive and early auxiliary diagnosis of postmenopausal osteoporosis in clinic. In addition, inhibitors of the miR-338 cluster have the efficacy of promoting osteogenesis and can be used for treating or preventing postmenopausal osteoporosis.
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机译：本发明提供的是MiR-338簇作为绝经后骨质疏松症的标志物。在本发明中，发现miR-338簇如miR-338-3 和/或miR-3065-5 p 在患者中高度表达通过绝经后骨质疏松症，它可以用作绝经后骨质疏松症的标志物，用于制备绝经后骨质疏松症的辅助诊断试剂盒，其可以特别检测组织中miR-338簇的表达水平，并用于非侵入性和临床绝经后骨质疏松症的早期辅助诊断。此外，miR-338簇的抑制剂具有促进骨发生的功效，可用于治疗或预防绝经后骨质疏松症。
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