COMBINED DRUG WITH ANTIVIRAL EFFECT AGAINST NEW SARS-COV-2 CORONAVIRUS

摘要

FIELD: medicine; biotechnology; virology; immunology.;SUBSTANCE: combined drug (CD) with an antiviral effect against SARS-CoV-2 coronavirus and related viruses is presented, provided that the genetic target, against which the specific component of this drug is directed, is identical. The combined drug for the prevention or treatment of coronavirus infection caused by SARS-CoV-2 contains: (i) the effective number of siRNA molecules directed against the genome of the SARS-CoV-2 virus, represented as two complementary chains characterized by the (+G)GAAGGAAGUUCUGUUGAA(+T)(+T)dT and UUCAACAGAACUUCCUUCC(+T)(+T)dT structure, where the modified nucleotides in the sense and antisense strand are represented by the LNA modification, (ii) a dendrimer cationic peptide with transfection activity characterized by the R₈K₄X₄K₂H₂KZC structure, where R is arginine; K is lysine; X is SEQ ID NO 3; H is histidine; Z is phenylalanine (F); C is cysteine or cysteine amide, (iii) a pharmacologically acceptable auxiliary agent (solvent). ;EFFECT: invention suppresses the replication of SARS-CoV-2 virus, which provides a new opportunity for treatment of COVID19 infection caused by this virus.;14 cl, 12 dwg, 9 ex