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Nutraceuticals Having Sustained Release for Improved Bioavailability and Method of Production

机译:具有持续释放的营养保健品,可提高生物利用度和生产方法

摘要

The present disclosure describes economical processes to improve the bioavailability of nutraceuticals by formulations that induce micronization and sustained release. The inventive process can be used to increase the solubility and bioavailability of lipophilic and moderately water-soluble nutraceuticals by combining excipients that increase the solubility and induce sustained release of the active compounds. The inventive process also can be used to increase the residence time of highly water-soluble nutraceuticals that are metabolized and eliminated quickly from the body, consequently increasing the therapeutic potential. The disclosed formulations advantageously are freely flowing powders that can be used to formulate with other ingredients into tablets, capsules, or the like; or used as bulk powders.
机译:本公开描述了通过诱导微粉化和持续释放的制剂改善营养制品的生物利用度的经济方法。本发明的方法可用于通过组合增加溶解度的赋形剂来增加亲脂性和中等水溶性营养营养件的溶解度和生物利用度,并诱导活性化合物的持续释放。本发明的方法还可用于增加高度水溶性营养保健品的停留时间,这些营养营养保健品是从体内迅速迅速地消除的,因此增加了治疗潜力。所公开的制剂有利地是可自由流动的粉末,其可用于与其他成分配制成片剂,胶囊等;或用作散装粉末。

著录项

  • 公开/公告号US2021113554A1

    专利类型

  • 公开/公告日2021-04-22

    原文格式PDF

  • 申请/专利权人 BIOACTIVES LLC;

    申请/专利号US202017126811

  • 发明设计人 DODDABELE L. MADHAVI;DANIEL I. KAGAN;

    申请日2020-12-18

  • 分类号A61K31/4745;A61K31/12;A61K31/05;A61K9/107;A61K9/16;A23L33/175;A23L33/105;A23L33/12;A61K31/198;

  • 国家 US

  • 入库时间 2022-08-24 18:20:33

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