Provided is a method of inhibiting tumor progression in a subject suffering from gastric cancer, including administering to said subject a pharmaceutical composition including an inhibitor of targeting PHF8-c-Jun-PKCα-Src-PTEN axis, or a pharmaceutically acceptable salt thereof. A method of determining a tumor progression state in a subject suffering from gastric cancer is also provided, which comprises providing a sample from the subject; detecting PHF8 expression level in the sample from the subject; and determining the tumor progression state of gastric cancer by the PHF8 expression level, wherein the PHF8 expression level is positively detected from moderate to strong expression indicating the subject suffering a late stage of gastric cancer.
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