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T CELL RECEPTORS TARGETING PIK3CA MUTATIONS AND USES THEREOF
T CELL RECEPTORS TARGETING PIK3CA MUTATIONS AND USES THEREOF
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机译:靶向PIK3CA突变的T细胞受体及其用途
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摘要
The presently disclosed subject matter provides for methods and compositions for treating cancer ( e.g., breast cancer). It relates to mutant PIK3CA-targeted TCRs that specifically target a mutant PIK3CA peptide (e.g., a human mutant PIK3CA peptide), and immunoresponsive cells comprising such TCRs. The presently disclosed mutant PIK3CA peptide-specific TCRs have enhanced immune-activating properties, including anti-tumor activity.
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