IDENTIFICATION OF METABOLOMIC SIGNATURES IN URINE SAMPLES FOR TUBERCULOSIS DIAGNOSIS

摘要

The authors of the present invention have identified a series of metabolic markers present in the urine samples collected from patients diagnosed of tuberculosis (TB, n=19), respiratory infections caused by Streptococcus pneumoniae (Rl, n=25) and healthy controls (HC, n=29). These metabolic markers selected are significantly differentiated between Healthy Controls (HC) and patients diagnosed of tuberculosis, between tuberculosis patients versus patients affected by respiratory infections caused by S. pneumoniae, and between patients affected by respiratory infections caused by S. pneumoniae and HC. These metabolic markers can thus be used in a non-invasive diagnostic method identifying and classifying patients.