HUMAN MONOCYTE CELL LINE AND USE OF SAME AS A CELL MODEL OF PHAGOCYTOSIS

摘要

The present invention concerns a human monocyte cell line expressing, in a stable and functional manner, human Fc gamma receptors (FcyR) CD16a, CD32 and CD64 on the surface, and a method for the in vitro evaluation of the phagocytic activity of the line. The present invention also concerns a method for the selection of antibodies having a high ADCP activity mediated by the human Fc gamma receptors (FcyR) CD16a, CD32 and/or CD64 and a method for the selection of an inhibitor of ADCP mediated by the human Fc gamma receptors (FcyR) CD16a, CD32 and/or CD64.