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DETECTING HOMOLOGOUS RECOMBINATION DEFICIENCIES (HRD) IN CLINICAL SAMPLES
DETECTING HOMOLOGOUS RECOMBINATION DEFICIENCIES (HRD) IN CLINICAL SAMPLES
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机译:检测临床样品中的同源重组缺陷(HRD)
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摘要
Disclosed herein are methods of identifying homologous recombination deficiency (HRD) in omics data, comprising generating a mutational spectrum from omics data; and using the mutational spectrum in a trained model to identify HRD. Further disclosed herein are methods of treating a tumor that has HRD score indicating significant HRD events, comprising: obtaining omics data from a tumor sample and generating a mutational spectrum from omics data; using the mutational spectrum in a trained model to identify HRD in the omics data from the tumor sample; identifying the cancer as likely responsive to treatment with a PARP inhibitor upon determination of HRD; and administering a PARP inhibitor treatment for the tumor upon determination of a high HRD score.
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