Preparation of sufentanil citrate and sufentanil base

摘要

PROBLEM TO BE SOLVED: To provide a preparation of sufentanil citrate and sufentanil base. The description of the present specification is a treatment method corresponding to the formation of sufentanil citrate from a sufentanil salt. One process involves forming sufentanil citrate in the presence of a polar non-aqueous solvent. Other processes involve the formation of sufentanil citrate in the presence of water. One aspect of the disclosure includes the process of forming sufentanil citrate from a sufentanil base in the presence of a polar non-aqueous solvent. [Selection diagram] None