Compositions and Methods for Amplification of Hematopoietic Stem Cells and Progenitor Cells and Treatment of Hereditary Metabolic Disorders

摘要

As used herein, compositions and methods useful for the amplification of hematopoietic stem cells and progenitor cells are provided. According to the compositions and methods described herein, hematopoietic stem cells and progenitor cells can be amplified by treatment with ex vivo, for example with aryl hydrocarbon receptor antagonists, and patients in need of hematopoietic stem cell transplantation therapy. Can be infused into patients such as. Therefore, what is provided herein is a method of treating a variety of related disorders, including, among other things, hereditary metabolic disorders. [Selection diagram] None