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COMPOSITIONS AND METHODS FOR INDUCING THE ACTIVATION OF IMMATURE MONOCYTIC DENDRITIC CELLS
COMPOSITIONS AND METHODS FOR INDUCING THE ACTIVATION OF IMMATURE MONOCYTIC DENDRITIC CELLS
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机译:诱导未成熟单核细胞的活化的组合物和方法
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摘要
The present invention provides methods for inducing the maturation of immature dendritic cells (DT) and for activating those cells without the use of a dendritic cell maturation agent. The activated DC can be used for inducing an antigen specific T cell response. Methods of the invention can also comprise the addition of a directional maturation agent, such as interferon gamama, to induce a Th-I and/or Th-2 bias in the response obtained. The present invention also provides dendritic cell populationns useful for activating and for inducing antigen specific T cells. Similarly, activated antigen specific T cell populations, and methods of making the same are provided.
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