Compositions and methods for inducing the activation of immature monocytic dendritic cells

摘要

The present invention relates to the induction of maturation of immature dendritic cells (DCs) and the activation of these cells without the use of dendritic cell maturation agents. Activated DCs can be used to induce antigen-specific T cell responses. The method of the present invention may also include the addition of an oriented maturing agent such as interferon gamma to induce TH-I and / or TH-2 bias in the resulting reaction. The invention also relates to dendritic cell populations useful for the activation and induction of antigen-specific T cells. Similarly, the present invention relates to activated antigen-specific T cell populations and methods for their production.