Pyrimidina-1,5(1,3)-dibenzenacycloheptaphane derivative as mutant epidermal growth factor receptor inhibitor
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机译:吡啶鎓-1,5(1,3) - 苄腺癌衍生物作为突变表皮生长因子受体抑制剂
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摘要
The present invention relates to a pyrimidinadibenzeneacycloheptaphan derivative represented by the following formula (I), a solvate thereof, a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition containing the same as an active ingredient, The pyrimidinadibenzeneacycloheptaphan derivative of the present invention effectively inhibits the growth of cancer cells and resistance to drugs caused by mutations in the tyrosine kinase domain of the epithelial growth factor receptor, or the growth of cancer cells having such resistance. Can be: [Formula I] .
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