Immune effector cells genetically engineered with CS1-specific chimeric antigen receptors
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机译:免疫效应细胞与CS1特异性嵌合抗原受体遗传设计
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摘要
Disclosed herein are chimeric antigen receptors (CAR) that can specifically recognize tumor- associated antigens (TAA) on multiple myeloma (MM) cells. Also disclosed are immune effector cells, such as T cells or Natural Killer (NK) cells, that are engineered to express these CARs. Therefore, also disclosed are methods of providing an anti-tumor immunity in a subject with MM that involves adoptive transfer of the disclosed immune effector cells engineered to express the disclosed CARs.
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