METHODS AND APPARATUS FOR IDENTIFYING ORGAN/TISSUE HEALTH STATUS USING TRANSCRIPTOMICS ANALYSIS OF LIQUID BIOPSY SAMPLES

摘要

An assay method is provided for determining the status of the health of a tissue within the body of a subject, wherein the tissue comprises an abundance of at least a first target protein, wherein assay comprises analysis of a liquid biopsy sample obtained from the subject, and wherein the liquid biopsy sample comprises at least a first cell free mRNA (cf-mRNA) that encodes the at least a first target protein. The assays and methods are useful in the diagnosis and treatment of liver health in a subject. In particular, methods and systems are provided for the diagnosis and treatment of fatty liver; non-alcoholic steatohepatitis (NASH); cirrhosis; liver disease; hepatitis; and liver cancer.