3 'UTR sequences for RNA stabilization

摘要

The present invention relates to the stabilization of RNA, particularly mRNA, and increase in mRNA translation. Specifically, the invention relates to the modification of RNA, particularly in vitro transcription RNA, which results in enhanced transcriptional stability and / or translation efficiency.5.(a) promoter;(b) nucleic acid sequences for introducing transferable nucleic acid sequences or transferable nucleic acid sequences;And (c) when transferred under the control of promoter (a),Is a nucleic acid sequence encoding a 3 'untranslated region in the transcriptThe nucleic acid sequences (b) and (c) under the control of promoter (a) areA common transcript can be generated by transferNucleic acid sequence transferred from nucleic acid sequenceIt is more active to increase the translation efficiency and / or stability of the nucleic acid sequence transcribed from the transferable nucleic acid sequenceProvide nucleic acid molecules.No selection