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PREDICTION TOOL FOR PATIENT IMMUNE RESPONSE TO A THERAPY

机译:患者免疫应对治疗的预测工具

摘要

Aspects and embodiments relate to a method and apparatus configured to perform that method. The method relates to generating an indication of relevance associated with a selected biological phenomenon indicative of condition of an immune system of a patient, that selected biological phenomenon being associated with response of a patient to a chosen therapy. The method comprises steps of: determining one or more measurable input parameters characteristic of the patient and associated with the biological phenomenon; mapping the one or more input parameters to a contribution to a score associated with the selected biological phenomenon; and combining the mapped contributions across the one or more input parameters to calculate the score associated with the selected biological phenomenon. A decision support system in accordance with aspects and embodiments may be configured to provide a score and/or visualisation, for example, a numerical value or graphical representation, relating to one or more underlying biological phenomena contributing to immune response or immune condition of a patient to a therapy. The underlying biological phenomena may be quantified using various biomarkers and/or measurable input parameters.
机译:方面和实施例涉及配置成执行该方法的方法和装置。该方法涉及产生与指示患者免疫系统状况的所选择的生物现象相关的相关性的指示,其选择的生物现象与患者对所选疗法的响应相关。该方法包括以下步骤:确定患者的一个或多个可测量的输入参数,并与生物现象相关联;将一个或多个输入参数映射到与所选生物现象相关的分数的贡献;并将跨越一个或多个输入参数的映射贡献组合来计算与所选生物现象相关的分数。根据方面和实施例的决策支持系统可以被配置为提供评分和/或可视化,例如,有关一种或多种潜在的生物现象,其有助于免疫应答或患者的免疫条件有关的数值或图形表示治疗。可以使用各种生物标志物和/或可测量的输入参数来量化潜在的生物现象。

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