Mutant cleavage type von Will brand factor

摘要

The present invention provides modified polypeptides that bind to factor VIII. The polypeptide comprises a truncated von Willebrand factor (VWF) comprising the sequence shown in SEQ ID NO: 3 or a fragment thereof or a sequence which is 90% identical thereto, said truncated VWF comprising S1, S3, L18, At least one modification in comparison to SEQ ID NO: 3 in at least one position selected from the group consisting of V42, S43, K149, N248, S279, V320, T325, Q395 and K418.