RECOMBINANT CANINE PD-1 FUSION PROTEIN AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF

摘要

A recombinant canine PD-1 fusion protein and a preparation method therefor and an application thereof. The fusion protein is formed by directly or indirectly linking the extracellular domain of a canine PD-1 protein or the mutant of the extracellular domain of the canine PD-1 protein to an Fc fragment. Compared with wild-type PD-1, the recombinant canine PD-1 fusion protein has higher affinity and a better effect, and provides more options for the immunotherapy of canine tumors.