ASSOCIATION BETWEEN 4 COPIES OF EXON 3 OF fAIM AND PROGRESSIVE CHRONIC KIDNEY DISEASE IN CATS

摘要

Individualized methods for the prevention and/or treatment of kidney disorders in cats are disclosed. The methods include identifying whether or not a cat is predisposed to developing kidney disorders by determining the total number of copies of Exon 3 in the feline apoptosis inhibitor of macrophages (fAIM) genes of the cat. Cats with at least 3 copies of Exon 3 are considered to be predisposed to kidney disorders to include tubulointerstitial fibrosis and/or Chronic Kidney Disease (CKD) and are provided with individualized kidney sparing therapies. Also disclosed is an in vitro amplification kit for determining the number of copies of Exon 3 in the feline apoptosis inhibitor of macrophages (fAIM) genes in a nucleic acid sample of interest.