Nanocapsule coated with chitosan comprising retinol or retinol derivatives and uses thereof

摘要

The present invention relates to a nanocapsule coated with chitosan containing retinol or a retinol derivative and a use thereof, and more specifically, a nanocapsule coated with chitosan on a nanoparticle containing retinol or a retinol derivative and a pluronic, and uses thereof In relation to, a method for manufacturing nanocapsules having a particle size of 500 nm or less, particularly 200 nm or less, and excellent stability was established, and chitosan is contained in nanoparticles including retinol or a retinol derivative and pluronic through the established manufacturing method. Coated nanocapsules were prepared. In addition, the antioxidant activity of the prepared nanocapsules was increased compared to the retinol or retinol derivative alone, and it was confirmed that the antioxidant activity was maintained even during long-term storage, and by confirming that the skin permeability was also significantly increased, the retinol or retinol of the present invention The nanocapsules coated with chitosan on nanoparticles containing derivatives and pluronics can be used not only for wrinkle improvement cosmetics, or for the development of cosmetics or pharmaceuticals for acne improvement or treatment, but also cosmetics and pharmaceutical fields that require antioxidant efficacy, It is expected to be used in the food industry.