Retro-amp;agr;-retinol (4,14-retro-retinol) derivatives and uses of retro-. alpha.-retinol

摘要

The present invention provides the retinoid compounds it is characterized in that the purifying of a molecular mass of about 302 dalton. Equally by it is provided by the present invention be a kind of method for improving in the growth of a unit of the environment of a vitamin a reduction, it includes the associative unit in the case where effective growth improves the amount with a kind of compound of a structure: ##STR1##, wherein the configuration of C6, C8, C10 and C12 double bond is independently Z or E, and is independently R or S in the absolute configuration of C-14; Wherein R.sub.1 is alkyl, alkyl halide, alcohol, ester, ether, aldehyde, ketone, carboxylic acid, acid ester, acid halide, amide, nitrile or amine; Wherein R.sub.2 be hydroxyl, halide, alkoxy, ester, alkyl, alcohol, ether, aldehyde, ketone, carboxylic acid, acid ester, nitrile, amine, azide, alkyl halide, acid halide, acid azide or amide; Or, wherein R.sub.1 and R.sub.2 are replaced by one 14,15- oxirane groups; Wherein pseudo-classic structure is α or γ. It further provides a kind of for improving the method or a kind of method for improving the immune response in a main body that pass through the transcription for the gene that biostearin in a unit is adjusted.