11-HYDROXYL-DERIVATIVES OF BILE ACIDS AND AMINO ACID CONJUGATES THEREOF AS FARNENSOID X RECEPTOR MODULATORS

摘要

The present invention provides a compound of formula I, a pharmaceutically acceptable salt, solvate or amino acid conjugate thereof, wherein R 1 is a hydroxy group, and R 2 , R 3 , R 4 , R 5 and R 6 Is as described herein. The present invention relates generally to selective FXR agonists and methods of making and using them. [Formula I]