Methods for multi-resolution analysis of cell-free nucleic acids

摘要

PROBLEM TO BE SOLVED: To provide a first bait set which selectively hybridizes to a first set of a genomic region of a nucleic acid sample and a second bait set which selectively hybridizes to a second set of the genomic region of a nucleic acid sample. To provide a method for enriching multiple genomic regions using. These baitset panels can be selectively enriched for one or more nucleosome-related regions of the genome, where the nucleosome-related regions are one or more genomes with different nucleosome occupancy. Different nucleosome occupancy, including genomic regions with base positions, is characteristic of the cell or histological type of origin or disease state. [Selection diagram] None