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BIODEGRADABLE POLYMER MICROSPHERE COMPOSITIONS FOR PARENTERAL ADMINISTRATION
BIODEGRADABLE POLYMER MICROSPHERE COMPOSITIONS FOR PARENTERAL ADMINISTRATION
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机译:可生物降解的聚合物微球组合物用于肠胃外给药
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摘要
Novel microsphere compositions for use in parenteral formulations are provided. The microspheres comprise a biodegradable polymer of a molecular weight greater than 10,000 daltons, an active therapeutic agent, and a cellulose-derived material such as ethyl cellulose, carboxymethyl cellulose, hydroxypropylmethyl cellulose, or sodium carboxymethyl cellulose. The microsphere compositions decreased deviation in mean microsphere diameter, improved drug entrapment, and improved microsphere stability.
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