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Methods of Inducing Metabolic Maturation of Human Pluripotent Stem Cells-Derived Hepatocytes
Methods of Inducing Metabolic Maturation of Human Pluripotent Stem Cells-Derived Hepatocytes
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机译:诱导人多能干细胞衍生肝细胞代谢成熟的方法
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摘要
Provided are methods of increasing metabolic maturation of an immature hepatocyte, by contacting an immature hepatocyte which expresses alpha-fetoprotein (AFP) and albumin with an effective amount of a fatty acid or a small molecule selected from the group consisting of: an amphipathic carboxylic acid Thiazolidinedione (TZD), WY-14643 (Pirinixic Acid), GW409544, GW6471, Leukotriene B4, GW 7647, Perfluorooctanesulfonic Acid, Perfluorooctanoic Acid, CP-775146, CP-865520, UNII-999KY5ZIGB, and Gemfibrozil. Also provided are isolated hepatocytes and uses thereof.
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