PROCESS FOR PREPARING ELAGOLIX SODIUM AND INTERMEDIATES THEREOF

摘要

The present invention provides improved processes for the preparation of elagolix and intermediates thereof. The intermediate of formula VII is achieved by a coupling reaction of a compound of formula V and a N-benzylidene protected compound of formula IV:; ;The present invention is suitable for a large-scale production, avoiding the use of potential genotoxic substances and can be performed under mild conditions.