首页> 外国专利> PROCESS FOR THE SYNTHESIS OF THE SODIUM SALT OF 4-(LR)-2-5-(2-FLUORO-3-METHOXYPHENYL)-3-2-FLUORO-6-(TRIFLUOROMETHYL)-PHENYLMETHYL-3,6-DIHYDRO-4-METHYL-2,6-DIOXO-L(2H)-PYRIMIDINYL-L- PHENYLETHYLAMINO-BUTANOIC ACID (ELAGOLIX SODIUM SALT) AND INTERMEDIATES OF SAID PROCESS

PROCESS FOR THE SYNTHESIS OF THE SODIUM SALT OF 4-(LR)-2-5-(2-FLUORO-3-METHOXYPHENYL)-3-2-FLUORO-6-(TRIFLUOROMETHYL)-PHENYLMETHYL-3,6-DIHYDRO-4-METHYL-2,6-DIOXO-L(2H)-PYRIMIDINYL-L- PHENYLETHYLAMINO-BUTANOIC ACID (ELAGOLIX SODIUM SALT) AND INTERMEDIATES OF SAID PROCESS

机译：合成4- [（L R / I>） - 2- [5-（2-氟-3-甲氧基苯基）-3 - [[2-氟-6- （三氟甲基） - 苯基]甲基] -3,6-二氢-4-甲基-2,6-二氧氧-1（2℃-L-苯基乙基]氨基] - 酸甲酸（Elagolix钠盐）和所述过程的中间体

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The present invention relates to a process for the preparation of the sodium salt of 4-[[(1R)-2-[5-(2-fluoro-3-methoxyphenyl)-3-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-3,6-dihydro-4-methyl-2,6-dioxo-l(2H)-pyrimidinyl]-l-phenylethyl]-amino]-butanoic acid, compound also known as Elagolix sodium salt, having the formula (I) reported below: 展开▼

机译：本发明涉及制备4- [（1 <1 r r℃） - 2- [5-（2-氟-3-甲氧基苯基）-3 - [[ 2-氟-6-（三氟甲基）苯基]甲基] -3,6-二氢-4-甲基-2,6-二氧氧-1（2℃-1） - 嘧啶基] -1-苯基乙基] - 氨基] - 丁酸，化合物，也称为Elagolix钠盐，具有以下内容（I）以下：展开▼

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公开/公告号WO2021044230A1

专利类型

公开/公告日2021-03-11

原文格式PDF

申请/专利权人 INDUSTRIALE CHIMICA S.R.L.;
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申请/专利号WO2020IB57065

发明设计人 LENNA ROBERTO;FASANA ANDREA;ORTIZ JERRY;
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申请日2020-07-27

分类号C07D239/54;C07D239/553;

国家 IB

入库时间 2022-08-24 17:41:30

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