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SH2 domain-based prognostic biomarker for chronic lymphocytic leukemia
SH2 domain-based prognostic biomarker for chronic lymphocytic leukemia
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机译:SH2基于结构域的慢性淋巴细胞白血病预后生物标志物
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摘要
The present disclosure provides methods and compositions for prognosing Chronic Lymphocytic Leukemia (CLL) or monitoring CLL therapy in a subject, by contacting a blood sample from a subject having CLL with one or more tyrosine phosphorylation (pTyr) probes to promote binding of tyrosine phosphorylated proteins in the blood sample to the one or more pTyr probes to generate pTyr probe-protein complexes; and detecting an amount of pTyr probe-protein complexes in the blood sample; wherein an amount of pTyr probe-protein complexes in the blood sample is compared to a control to indicate expected progression of CLL, or therapeutic efficacy of CLL therapy in the subject.
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