GALNAC CONJUGATED MODIFIED OLIGONUCLEOTIDE AS MIR-122 INHIBITOR HAVING HCV ANTIVIRAL ACTIVITY WITH REDUCED HYPERBILIRUBINEMIA SIDE-EFFECT

摘要

Described herein are compositions and methods for the inhibition of miR-l22 activity. The compositions have certain nucleoside modifications that yield potent inhibitors of miR-l22 activity and comprise moieties that facilitate delivery to the liver. The compositions may be administered to subjects infected with hepatitis C virus, as a treatment for hepatitis C virus and related conditions.