首页>
外国专利>
Fusion protein Slit2D2(C386S)-HSA and use thereof in treatment of fibrotic diseases
Fusion protein Slit2D2(C386S)-HSA and use thereof in treatment of fibrotic diseases
展开▼
机译:融合蛋白Slit2D2(C386S)-HSA及其用途治疗纤维化疾病
展开▼
页面导航
摘要
著录项
相似文献
摘要
The present invention relates to the field of biomedical technology, in particular to a fusion protein Slit2D2(C386S)-HSA and use thereof in the treatment and/or prevention of fibrotic diseases. In the fusion protein, the amino acid residue is mutated on the basis of the Slit2D2 domain, which improves the stability of the fusion protein compared with the native protein. The above fusion protein is obtained by fusing Slit2D2(C386S) with HSA protein, which prolongs the metabolism time of the drug while improving the stability of the drug. The fusion protein provided by the present invention is more effective than the positive control drug in the prevention and treatment of fibrotic diseases, particularly pulmonary fibrosis, and shows good drug-forming properties.
展开▼