Convection-enhanced transmission cranial implant device compatible with magnetic resonance imaging and related methods

摘要

Provided herein are magnetic resonance imaging (MRI) compatible, convection enhanced delivery (CED) cranial implant devices and related methods for performing a variety of treatment and/or monitoring applications. In one aspect, the cranial implant device includes a cranial implant housing configured for intracranial implantation in a subject's cranial opening. The cranial implant housing comprises at least one fluid circuit comprising a substantially anatomically compatible shape, at least first and second surfaces, and at least one cavity and at least one port in fluid communication with the cavity through the at least second surface. And the cavity may contain or contain at least one fluid therapeutic agent. The device also includes at least one CED pump operably connected to a fluid circuit, the CED pump being actuated to the port to maintain at least one positive pressure gradient of the fluid therapeutic agent in which the fluid conduit is at least proximate the outlet of the fluid conduit. When operatively connected, it is configured to convey the fluid therapeutic agent from the cavity through the at least one fluid conduit. In addition, the device also comprises at least one power source operably connected to at least the CED pump. The cranial implant housing, CED pump, and power source are typically made of one or more MRI compatible materials. Other aspects relate to various methods of treating neurologically related diseases using a cranial implant device, a method of monitoring the administration of a therapeutic agent in a plurality of subjects, and a method of manufacturing a cranial implant device and a surgical method.