ANTI-GP73 ANTIBODIES AND IMMUNOCONJUGATES

摘要

The present invention relates to an antigen-binding molecule, preferably an antibody or antigen-binding fragment thereof, that specifically binds to GP73, or an antigenic portion thereof, wherein the antigen-binding molecule binds to an epitope in the extracellular portion of GP73. And it is usually internalized into cells after proteolytic cleavage. The invention also relates to an immunoconjugate comprising an antigen-binding molecule, specifically an anti-GP73[deg.] antibody, or an antigen-binding fragment thereof. The antigen-binding molecules and immunoconjugates of the present invention may be administered alone or as a therapeutic conjugate alone or in combination with other naked antibodies, or therapeutic agents, or other immunoconjugates, or may be administered as a diagnostic conjugate. have. The invention also relates to a nucleotide sequence encoding an anti-GP73 antibody, and an immunoconjugate, a vector and a host cell comprising the nucleotide sequence, and a method of preparing an anti-GP73-antibody. The antigen-binding molecules, antibodies and compositions of the present invention are useful for diagnosis and therapeutic applications of diseases in which the expression of GP73 is altered, specifically GP73 overexpression, such as cancer.