RNA METHYLTRANSFERASE INHIBITOR, SCREENING METHOD THEREFOR, ANTI-CANCER AGENT EFFICACY ASSESSMENT MARKER, AND KIT FOR EFFECTIVELY PREDICTING FTSJ1 INHIBITOR

摘要

An RNA methyltransferase inhibitor containing at least one type of compound selected from the group consisting of sulfonamide-based compounds represented by general formula (1) and pyrazoline-based compounds represented by general formula (2). Formula (1) [In formula (1), R¹ represents any of groups (1-1) to (1-5) below. (1-1) a nitrogen-containing heterocyclic group having a substituent, (1-2) a cycloalkyl group having a substituent, (1-3) an alkyl group having a substituent, (1-4) a pyrazolyl amino group, (1-5) a phenyl group; R² represents (2-1) a hydrogen atom or (2-2) an alkyl group. R³ represents any of groups (3-1) to (3-9) below. (3-1) a phenyl group, (3-2) a naphthalene group, (3-3) a nitrogen- or sulfur-containing heterocyclic group, (3-4) a dihydrocarbostyril group, (3-5) a tetrahydronaphthalene group, (3-6) an indanyl group, (3-7) a benzodioxolyl group, (3-8) a benzodiazepinezole group, (3-9) a dihydrobenzodioxepinyl group; wherein each group represented by (3-1) to (3-9) may further have a substituent. Alternatively, R¹ and R² may bond to each via a nitrogen atom bonded thereto to form a ring.] Formula (2) [In formula (2), n represents an integer of 2 to 4. R⁴ is the same or different and represents any of groups (4-1) to (4-34). (4-1) a phenyl group, (4-2) a phenylsulfonyl group, (4-3) an alkylcarbonyl group, (4-4) an aminothiocarbonyl group, (4-5) a benzodioxolyl group, (4-6) an alkylsulfonyl group, (4-7) an adamantanecarbonyl group, (4-8) a benzopyrazil group, (4-9) a phenylcarbonyl group, (4-10) a naphthalene group, (4-11) a furylcarbonyl group, (4-12) a thienylcarbonyl group, (4-13) a kinazolyl group, (4-14) a kinoxalyl group, (4-15) a hydroxy group, (4-16) an alkenyl group, (4-17) a thiazolyl group, (4-18) a cycloalkylcarbonyl group, (4-19) an aminocarbonyl group, (4-20) a furyl group, (4-21) a thienyl group, (4-22) a pyridyl group, (4-23) a cycloalkenyl group (4-24) an alkyl group, (4-25) a pyrazolyl group (4-26) a quinolyl group, (4-27) an alkenylcarbonyl group, (4-28) a benzopyranyl group, (4-29) a benzopyrimidyl group, (4-30) a pyrrolidino alkylcarbonyl group, (4-31) a quinolylcarbonyl group, (4-32) an alkoxycarbonyl group, (4-33) a morpholino group, (4-34) a pyrrolidino carbonylalkoxy group, (4- 35) a benzodioxy-6-yl group; wherein each group represented by (4-1) to (4-35) may further have a substituent group. The bond between the 4-position carbon atom and the 5-position carbon atom of the pyrazole skeleton represents a single bond or a double bond. Alternatively, the two adjacent carbon atoms constituting the pyrazoline ring may bond to each other to form a ring. Alternatively, the nitrogen atom and the carbon atom adjacent thereto, which constitute the pyrazoline ring, may bond to each other to form a ring.]