LOW AFFINITY RED FLUORESCENT INDICATORS FOR IMAGING CA2+ IN EXCITABLE AND NONEXCITABLE CELLS

摘要

The present disclosure relates to genetically encoded low affinity, fluorescent Ca2+ indicators, which may be targeted to endoplasmic reticulum, the sarcoplasmic reticulum and/or the mitochondria. It also relates to polynucleotides, vectors and host cells which encode or include such low affinity Ca2+ indicators, and methods of detecting Ca2+ levels in a cell using such indicators.