Biarylamides with modified sugars for the treatment of diseases associated with the heat shock protein pathway

摘要

Biarylamide and coumarin-based compounds with modified sugars for the treatment of diseases associated with the heat shock protein pathway are provided. This compound has the following formula, wherein the variables are as defined herein. Formulas (I), (II), (III), (IV) and (V): Pharmaceutical compositions of the above compounds are also provided. These biarylamides and coumarin-based derivatives with modified sugars are useful for the treatment and prevention of neurological disorders, such as neurodegenerative diseases and neurological damage disorders, such as diseases and disorders, including diabetic peripheral neuropathy. .