PROCESS FOR THE SYNTHESIS OF 2-(2S)-1-AZABICYCLO2.2.2OCT-2-YL-6-(3-METHYL-1H-PYRAZOL-4-YL)THIENO3,2-dPYRIMIDIN-4(3H)-ONE

摘要

The present invention provides processes and synthetic intermediates for the synthesis of 2-[(2S)-1-azabicyclo[2.2.2]oct-2-yl]-6-(3-methyl-1H-pyrazol-4-yl)thieno[3,2-d]pyrimidin-4 (3H)-one or a salt, hydrate, or tautomer thereof, or any combination thereof, which are Cdc7 kinase inhibitors, and are useful for the treatment of disorders of cell proliferation, particularly cancer, and other disorders associated with Cdc7 activity.