A process for preparing 2-sulphanilamidopyrazine and the 2-sulphanilamidopyrazine resulting therefrom

摘要

2-Sulphanilamidopyrazine is prepared by reacting 2-aminopyrazine with a benzene-sulphonyl chloride which carries in the p-position an acylamino group convertible to an amino group by hydrolysis, such as acetylamino or propionylamino, and finally hydrolysing the group so convertible, to give the required product. In an example, p-acetylaminobenzene sulphonyl chloride reacts with 2-aminopyrazine in pyridine to give 2-(N4-acetylsulphanilamido) pyrazine which is hydrolysed by hydrochloric acid in alcohol to give 2-sulphanilamidopyrazine.