Proprocedimiento of preparation of new compounds derived from hydroximethylpregnan (Machine-translation by Google Translate, not legally binding)

摘要

Preparation process for the compounds of the general formula ** (See formula) ** in which R1 represents (see formula) (alpha or beta) or (see formula), (alpha or beta), where R 'is an acyl radical, R2 represents H2, O or (see formula) and R3 represents hydrogen or an alkyl radical, or N (R3) 2 represents a heterocycle having from 4 to 6 carbon atoms to hydrogen in 5 can be found in alpha or beta position if the compound is saturated; otherwise, the core A may have one or two double bonds, and the salts of said compounds, characterized in that a 20-hydroxymethyl-21-hydroxypregnane is reacted with the action of a functional derivative of a sulfonic acid, the sulfonate of the resulting 20-hydroxymethyl 21-hydroxypregnane with an alkali metal halide, a 20-halogenomethyl-21-halogenopregnane derivative is obtained, this is transformed by condensation with a dialkyl amine in corresponding 20-aminomethyl-21-aminopregnane, which is convert, if necessary, into a salt. (Machine-translation by Google Translate, not legally binding)