The invention comprises compounds of the formula FORM:0948879/C2/1 and non toxic and quaternary salts thereof wherein A is a hydrogen atom or an alkanoyl radical containing 1 to 6 carbon atoms, R is a hydrogen atom or an alkyl radical containing 1 to 6 carbon atoms; Alk is an alkylene radical containing 2 to 5 carbon atoms which separates the R-N and Z functions by at least two carbon atoms; the dotted line indicates the optional presence of a double bonded linkage between carbon atoms 5 and 6; and Z is a radical of the general formula: -NR1R11 or the general formula FORM:0948879/C2/2 wherein R1 and R11 are each a hydrogen atom or, an alkyl radical containing 1 to 6 carbon atoms; L is methylene, epoxy or methylimino and n is O or 1. Such compounds may be prepared (a) by treating a 17-ketone with an amino-alkylamine and reducing the resultant imino compound (b) reacting a 17-ketone with an amino-alkylamine and formic acid and hydrolysing or reducing the resultant 17b -[N-(amino-alkyl) formamido] derivative; (c) alkylating a 17-ketone with a formamide of the formula H-CO-NH-R, hydrolysing the formamido compound thus formed, reacting the resultant amino compound with an a ,b -olefinic nitrile to obtain the corresponding N-(b -cyanoalkyl) amino derivatives which are reduced; (d) reacting a 17-amino compound with a haloalkanoyl halide to obtain a 17-haloalkyl-mido 3-haloalkyl ester, and reacting this compound with a primary amine to obtain a monoalkylaminoalkylamido compound which is reduced.
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