New economic procedure for fermentation and purification of tetracyclines. (Machine-translation by Google Translate, not legally binding)

摘要

"New economic process of fermentation and purification of tetracyclines", of high yield, characterized by the fact of fermenting, in an aerobic submerged manner, an aqueous culture medium containing a source of carbon and sodium assimilable, mineral salts, including metal salts alkaline-earthy and N, N'-dibenzylethylenediimine of the formula: ** (See formula) ** by any species of Streptomyces, including its spontaneous and artificial mutants, producer of a member of the tetracycline group, at a temperature between 22 and 36º C, and to effect the isolation of the antibiotic agent in the form of an earthy alkaline dibencylethylenediiminic molecular complex metal, with eventual subsequent release thereof, the corresponding tetracycline, in the form of an acid or base salt. (Machine-translation by Google Translate, not legally binding)