Compositions and method for the treatment of vascular spasms

摘要

The invention comprises a pharmaceutical composition having activity as a coronary dilator and containing as the active ingredient 11-(5B-androstan-11-one-17b -yl)-31, 51, 81-trioxa-bicyclo-[21212]-octane derivatives of the general formula FORM:1014052/A5-A6/1 where Z represents a hydrogen atom, and acyl group derived from an organic carboxylic acid having 1-18 carbon atoms or an alkyl group having 1-6 carbon atoms, in association with a pharmaceutical vehicle. Administration may be orally as a tablet, pill, capsule, powder, syrup or elixir by injection in an injectable sterile liquid medium, or rectally as a suppository. Nutrients, such as sugar starch, lactose, pectin, yeast extract and vitamins may also be added. Specification 988,801 also is referred to.