Catalytic process for production of tripiperideine bases

摘要

Organic bases, apparently corresponding to the molecular formula C15H27N3, are prepared by contacting a mixture of ammonia and tetrahydrofurfuryl alcohol with finely divided palladium as catalyst, at elevated temperature. The palladium may be 0.04% by weight supported on alumina and the reaction temperature from 200 DEG to 500 DEG C. 1 to 10 moles of ammonia are used per mole of tetrahydrofurfuryl alcohol and 1 to 10 moles of hydrogen may also be added to the mixture. Isolation of the various tripiperideines is described. Isotripiperideine may be further converted into 2:31-bipiperidyl, piperidine and 2:31-bipyridyl by hydrogenation.