process for the preparation of analgesic active, - 1h - azepinederivaten,method for preparation of pharmaceutical preparations, azepinederivaten - 1h - and the application obtained formed pharmaceutical preparations.

摘要

Analgesic hexahydro 1H azeoine derivs.. N3A. And their acid addn. and quat. ammonium salts are new cpds. of formula (I): (where R1 = H, (1-6C) alkyl, PhCH2, or (2-6C) alkanoyl; R2 = (1-6C)alkyl; R3 = H, (1-6C) alkyl, (2-6C) alkenyl, (2-6C) alkynyl, cyclopropylmethyl (2-6C) alkanoyl, CO2 alkyl, CHO, phenacyl, phenethyl or beta-benzoylethyl, (Ph rings may be substd); n = 3 or 4; and m = 0 or 1; with the proviso that n + m = 4; R = H or (1-6C) alkyl if m = 0 or H if m = 1). Used as analgesic and analgesic antagonists in a dose of 10-200 mg./kg.