Cpds. where R = H, benzyl, lower alkyl A = -CH=CH-, or -CH2CH2- R' = H or halogen (not both R1 = H) (I) have oestrogenic activity, or aid in increasing th

摘要

Cpds. (I) where R = H, benzyl, lower alkyl A = -CH=CH-, or -CH2CH2- R' = H or halogen (not both R' = H) (I) have oestrogenic activity, or aid in increasing the rate of growth in meat-producing animals, (cattle, lambs, and swine). Prepns. of (II) from (II; Z = H) (fermentation oestrogenic substance (FES)) are listed in SA. 758/SA. 359 and SA. 759/SA. 360. Prepn. of (I; R = Me, A = -CH=CH-, R'=Cl) (II; Z = Me, A = -CH=CH-) in Et2O was added to PCl5 at 0 deg., and mixture was stirred to give title-cpd.